Sustainable Inhalable Anti-Infective Microparticle Manufacturing Through Life Cycle and Cost Analysis with Machine Learning Optimization

This study compares spray drying, spray freeze-drying, and supercritical antisolvent processing for inhalable formulations of tobramycin and molnupiravir. Particle characterization and machine learning are combined with gate-to-gate LCA and life cycle costing to examine trade-offs among formulation properties, manufacturing impacts, and cost.

DOI: 10.1021/acssusresmgt.5c00530

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